An immunohistochemical study on expression of CD44v6 pro- tein in human gallbladder carcinoma

摘要

Objective To investigate the clinical significances of CD44v6 protein expression in human gallbladder carcinoma (GBC). Methods The immunohistochemical technique was used to detect the CD44v6 protein expression in 40 cases of GBC, 12 cases of chronic cholecystitis, 6 cases of adenoma and 4 cases of adenomyomatous hyperplasia. Results The positive rate of CD44v6 expression in gallbladder carcinoma and benign lesions was 72.5 /100 and 0 /100, respectively (P＜ 0.01), and it also correlated with the lymph node metastasis, pathologic differentiation and clinic staging, but there was no correlation among pathological types.