The expression of p53 protein and p21~WAF1/cipl/sdil in gastric

摘要

Objective To study the relation align p53, p21 protein, p21 gene and their clinical significances in 40 gastric comparing with normal gastric tissues. Methods In this study, the p53 and p21 protein were investigated in 40 gastric carcinomas using IHC (Immunohistochemistry). At the same time, the possible presence of p21 gene mutation was also analyzed by silver staining PCR-SSCP method. Results The abnormal expression of p53 and p21 protein occurs only in gastric carcinoma; The expression of p53 protein and p21 is not related tot he clinico pathological features.