Innervation of sensory nerve terminals in rat lumbar intervertebral disc and posterior longitudinal ligament

摘要

Conclusion This study demonstrates an extensive distribution of SP and CGRP immunoreactive nerve fibers throughout the PLL and the peripheral annulus fibrosus and provides an illustration of this distribution. This finding supports a role for the disc as a source of low back pain and provides the neuroanatomic foundation of the disc-genic pain. Objective To investigate the distribution of sensory nerve terminals in the lumbar intervertebral disc And posterior longitudinal ligament(PLL)in an animal model. Methods Immunohistochemical method was used to Visualize nerve terminals with antibodies of substance P(SP)and calcitonin gene-related peptide(CGRP), and to Characterize sensory nerve terminals on sections from lumbar interverbral disc and posterior longitudinal ligament(PLL) Of the Sprague Dawley rats.