Selective ERK Activation Differentiates Mouse and Human Tolerogenic Dendritic Cells Expands Antigen-Specific Regulatory T Cells and Suppresses Experimental Inflammatory Arthritis

摘要

ObjectiveMost therapeutic treatments for autoimmune arthritis rely on immunosuppressive drugs, which have side effects. Although a previous study by our group showed that specific ERK activation suppressed immune responses, its application in a therapeutic setting has never been tested. The aim of the present study was to define the ERK-dependent immunosuppressive mechanisms and to apply selective ERK activation for the treatment of experimental inflammatory arthritis.