Near real‐time vaccine safety surveillance using electronic health records—a systematic review of the application of statistical methods

摘要

PurposePre‐licensure studies have limited ability to detect rare adverse events (AEs) to vaccines, requiring timely post‐licensure studies. With the increasing availability of electronic health records (EHR) near real‐time vaccine safety surveillance using these data has emerged as an option. We reviewed methods currently used to inform development of similar systems for countries considering their introduction.