T‐type calcium channels contribute to NMDA receptor independent synaptic plasticity in hippocampal regular‐spiking oriens‐alveus interneurons

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12246-list-0001">Regular‐spiking interneurons in the hippocampal stratum oriens exhibit a form of long‐term potentiation of excitatory transmission that is independent of NMDA receptors but requires co‐activation of Ca²⁺‐permeable AMPA receptors and group I metabotropic glutamate receptors.We show that T‐type Ca²⁺ channels are present in such interneurons.Blockade of T‐type currents prevents the induction of long‐term potentiation, and also interferes with long‐lasting potentiation induced either by postsynaptic trains of action potentials or by pairing postsynaptic hyperpolarization with activation of group I metabotropic receptors.Several Ca²⁺ sources thus converge on the induction of NMDA receptor independent synaptic plasticity.