The effects of height and BMI on prostate cancer incidence and mortality: a Mendelian randomization study in 20848 cases and 20214 controls from the PRACTICAL consortium

摘要

BackgroundEpidemiological studies suggest a potential role for obesity and determinants of adult stature in prostate cancer risk and mortality, but the relationships described in the literature are complex. To address uncertainty over the causal nature of previous observational findings, we investigated associations of height- and adiposity-related genetic variants with prostate cancer risk and mortality.