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Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals

机译:基于全身生理学的药代动力学方法的开发以评估老年人的药物药代动力学

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摘要

BackgroundBecause of the vulnerability and frailty of elderly adults, clinical drug development has traditionally been biased towards young and middle-aged adults. Recent efforts have begun to incorporate data from paediatric investigations. Nevertheless, the elderly often remain underrepresented in clinical trials, even though persons aged 65 years and older receive the majority of drug prescriptions. Consequently, a knowledge gap exists with regard to pharmacokinetic (PK) and pharmacodynamic (PD) responses in elderly subjects, leaving the safety and efficacy of medicines for this population unclear.
机译:背景技术由于老年人的脆弱性和脆弱性,传统上,临床药物开发偏向年轻人和中年成年人。最近的努力已开始纳入儿科检查的数据。尽管如此,即使65岁及以上的老人接受了大多数药物处方,老年人在临床试验中的代表性仍然不足。因此,在老年受试者中关于药代动力学(PK)和药效学(PD)反应存在知识差距,因此尚不清楚该人群药物的安全性和有效性。

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