Pharmacokinetics Pharmacodynamics and Population Pharmacokinetic/Pharmacodynamic Modelling of Bilastine a Second-Generation Antihistamine in Healthy Japanese Subjects

摘要

Background and objectivesBilastine is a novel second-generation antihistamine for the symptomatic treatment of allergic rhinitis and urticaria. The objective of this study was to evaluate the pharmacokinetics, pharmacodynamics, and tolerability of bilastine following single and multiple oral doses in healthy Japanese subjects. The pharmacokinetic and pharmacodynamic profiles were compared with those reported in Caucasian subjects.