Population pharmacokinetic and covariate analyses of intravenous trastuzumab (Herceptin®) a HER2-targeted monoclonal antibody in patients with a variety of solid tumors

摘要

PurposeThe aim of the study was to characterize the population pharmacokinetics (PK) of the intravenous formulation of trastuzumab, assess the impact of patient and pathological covariates on trastuzumab PK, and perform simulations to support dosing recommendations in special situations.