Self-Reported Habitual Short Sleep Duration Is Associated with Endothelial Fibrinolytic Dysfunction in Men: A Preliminary Report

摘要

Study Objectives:Habitual short sleep duration is associated with increased cardiovascular disease morbidity and mortality resulting from atherothrombotic events. The mechanisms responsible for this heightened cardiovascular risk are not fully understood. The capacity of the endothelium to release tissue-type plasminogen activator (t-PA), the primary activator of the fibrinolytic system, is a key endogenous defense mechanism against intravascular fibrin deposition and thrombosis. We tested the hypothesis that endothelial t-PA release is impaired in adults who sleep less than 7 hight compared with adults who sleep between 7 and 9 hight.