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>A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model
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A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model
ObjectivesThere is a need for better, noninvasive quantitative biomarkers for assessing the rate of progression and possible response to therapy in spinal muscular atrophy (SMA). In this study, we compared three electrophysiological measures: compound muscle action potential (CMAP) amplitude, motor unit number estimate (MUNE), and electrical impedance myography (EIM) 50 kHz phase values in a mild mouse model of spinal muscular atrophy, the Smn1c/c mouse.
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机译：目的需要一种更好的，非侵入性的定量生物标志物，以评估脊髓性肌萎缩症（SMA）的进展速度和对治疗的可能反应。在这项研究中，我们比较了脊髓性肌萎缩的轻度小鼠模型Smn1中的三种电生理学指标：复合肌肉动作电位（CMAP）幅度，运动单位数估计（MUNE）和电阻抗肌成像（EIM）50 kHz相位值。 c / c 鼠标。
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