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Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway

机译：肝细胞生长因子通过PI3K，Akt，c-Src和AP-1信号通路增加人成骨细胞中骨桥蛋白的表达

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BackgroundHepatocyte growth factor (HGF) has been demonstrated to stimulate osteoblast proliferation and participated bone remodeling. Osteopontin (OPN) is a secreted phosphoglycoprotein that belongs to the SIBLING family and is present during bone mineralization. However, the effects of HGF on OPN expression in human osteoblasts are large unknown.

机译：背景已证明肝细胞生长因子（HGF）可以刺激成骨细胞增殖并参与骨骼重塑。骨桥蛋白（OPN）是一种分泌的磷酸糖蛋白，属于SIBLING家族，存在于骨矿化过程中。但是，HGF对人成骨细胞中OPN表达的影响尚不清楚。

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期刊名称 PLoS Clinical Trials
作者
Hsien-Te Chen; Hsi-Kai Tsou; Chia-Hao Chang; Chih-Hsin Tang;
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年(卷),期 2009(7),6
年度 2009
页码 e38378
总页数 11
原文格式 PDF
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机译：凝血酶通过人软骨细胞中的PKCδ/ c-Src / EGFR / PI3K / Akt / AP-1信号通路促进基质金属蛋白酶-13表达。
2. Inducing effects of hepatocyte growth factor on the expression of vascular endothelial growth factor in human colorectal carcinoma cells through MEK and PI3K signaling pathways [J] . ZHANG Yu-hua, WEI Wei, XU Hao, 中华医学杂志（英文版） . 2007,第009期

机译：通过MEK和PI3K信号通路诱导肝细胞生长因子对人大肠癌细胞血管内皮生长因子表达的影响
3. Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways [J] . Zeyuan Cao, Yunyi Xie, Le Yu, Stem Cell Research & Therapy . 2020,第1期

机译：肝细胞生长因子（HGF）和干细胞因子（SCF）通过通过PI3K / AKT，ERK1 / 2和Stat3信号传导途径保持线粒体函数，在长期膨胀期间保持人骨髓间充质干细胞（HBMSC）的茎。
4. Thymosin β_4 Upregulates the Expression of Hepatocyte Growth Factor and Downregulates the Expression of PDGF-β Receptor in Human Hepatic Stellate Cells [C] . ELENA BARNAEVA, AGLADZE NADEZHDA, EWALD HANNAPPEL, . 2007

机译：胸腺素β_4上调人肝星状细胞中肝细胞生长因子的表达并下调PDGF-β受体的表达
5. Crosstalk between the TGF-beta/Smad and PI3K/Akt pathways in the human epithelial MCF10A cell lineage and implications of signaling inhibitors. [D] . Zheng, Jie. 2009

机译：人上皮MCF10A细胞谱系中TGF-beta / Smad和PI3K / Akt通路之间的串扰和信号抑制剂的含义。
6. Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes [O] . Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, 2013

机译：凝血酶通过人软骨细胞中的PKCδ/ c-Src / EGFR / PI3K / Akt / AP-1信号通路促进基质金属蛋白酶-13表达。
7. Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway [O] . Chen, Hsien-Te, Tsou, Hsi-Kai, Chang, Chia-Hao, 2012

机译：肝细胞生长因子通过PI3K，Akt，c-Src和AP-1信号通路增加人成骨细胞中骨桥蛋白的表达

Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c-Src, and AP-1 Signaling Pathway

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