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Resveratrol Attenuates the Na+-Dependent Intracellular Ca2+ Overload by Inhibiting H2O2-Induced Increase in Late Sodium Current in Ventricular Myocytes

机译：白藜芦醇通过抑制H2O2诱导的心室肌细胞晚钠电流增加来减轻Na +依赖性细胞内Ca2 +超载。

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Background/AimsResveratrol has been demonstrated to be protective in the cardiovascular system. The aim of this study was to assess the effects of resveratrol on hydrogen peroxide (H2O2)-induced increase in late sodium current (I Na.L) which augmented the reverse Na⁺-Ca²⁺ exchanger current (I NCX), and the diastolic intracellular Ca²⁺ concentration in ventricular myocytes.

机译：背景/目的白藜芦醇已被证明对心血管系统具有保护作用。这项研究的目的是评估白藜芦醇对过氧化氢（H2O2）诱导的后期钠电流（I Na.L）增加的影响，后者增加了反向Na ^{+ -Ca ^{2 + 交换电流（I NCX）和心室肌细胞中舒张期细胞内Ca ^{2 + 的浓度。}}}

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期刊名称 PLoS Clinical Trials
作者
Chunping Qian; Jihua Ma; Peihua Zhang; Antao Luo; Chao Wang; Zhiqiang Ren; Linghao Kong; Shuo Zhang; Xiaojing Wang; Ying Wu;
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年(卷),期 2009(7),12
年度 2009
页码 e51358
总页数 10
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专利

1. Ketamine attenuates the Na+-dependent Ca2+ overload in rabbit ventricular myocytes in vitro by inhibiting late Na+ and L-type Ca2+ currents [J] . An-tao LUO, Zhen-zhen CAO, Yu XIANG, 中国药理学报：英文版 . 2015,第011期

机译：氯胺酮通过抑制晚期Na +和L型Ca2 +电流来减轻兔心室肌细胞Na +依赖性Ca2 +超负荷
2. Ranolazine attenuates the enhanced reverse Na+-Ca2+ exchange current via inhibiting hypoxia-increased late sodium current in ventricular myocytes [J] . WangX.-J., WangL.-L., FuC., Journal of pharmacological sciences. . 2014,第3期

机译：雷诺嗪通过抑制心室肌细胞缺氧增加的晚期钠电流来减弱增强的反向Na + -Ca2 +交换电流
3. Ranolazine Attenuates the Enhanced Reverse Na+-Ca2+ Exchange Current via Inhibiting Hypoxia-Increased Late Sodium Current in Ventricular Myocytes [J] . Chen Fu, Ji-Hua Ma, Lei-Lei Wang, Journal of pharmacological sciences. . 2014,第3期

机译：雷诺嗪通过抑制缺氧增加心室肌细胞中的后期钠电流来减弱增强的反向Na + -Ca2 +交换电流。
4. Arrhythmogenic Mechanism of the Enhanced Late Sodium Current in Human Ventricular Myocytes - a Simulation Study [C] . Wei Wang, Shanzhuo Zhang, Yong Xu, Computing in Cardiology Conference . 2019

机译：心室肌细胞后期钠电流增加的心律失常机理-模拟研究
5. The contribution of sodium -calcium exchange to excitation -contraction coupling in isolated left ventricular myocytes from failing human heart [D] . Mattiello, Julian Antony 2000

机译：钠 - 钙交换对孤立的左心室肌细胞的激发促进耦合的贡献
6. Ketamine attenuates the Na+-dependent Ca2+ overload in rabbit ventricular myocytes in vitro by inhibiting late Na+ and L-type Ca2+ currents [O] . An-tao Luo, Zhen-zhen Cao, Yu Xiang, 2015

机译：氯胺酮通过抑制晚期Na +和L型Ca2 +电流来减轻兔心室肌细胞中Na +依赖性Ca2 +超负荷
7. Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytes. [O] . Chunping Qian, Jihua Ma, Peihua Zhang, 2012

机译：白藜芦醇通过抑制H（2）O（2）诱导的心室肌细胞晚期钠电流增加来减弱Na（+）依赖性细胞内Ca（2+）过载。

Resveratrol Attenuates the Na+-Dependent Intracellular Ca2+ Overload by Inhibiting H2O2-Induced Increase in Late Sodium Current in Ventricular Myocytes

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