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Partially Randomized, Non-Blinded Trial of DNA and MVA TherapeuticVaccines Based on Hepatitis B Virus Surface Protein for Chronic HBVInfection

机译：DNA和MVA治疗的部分随机，无盲试验基于乙型肝炎病毒表面蛋白的慢性乙肝疫苗感染

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BackgroundChronic HBV infects 350 million people causing cancer and liver failure. We aimed to assess the safety and efficacy of plasmid DNA (pSG2.HBs) vaccine, followed by recombinant modified vaccinia virus Ankara (MVA.HBs), encoding the surface antigen of HBV as therapy for chronic HBV. A secondary goal was to characterize the immune responses.

机译：背景慢性HBV感染3.5亿人，导致癌症和肝功能衰竭。我们旨在评估质粒DNA（pSG2.HBs）疫苗的安全性和功效，然后评估编码HBV表面抗原的重组修饰牛痘病毒安卡拉（MVA.HBs）作为慢性HBV的治疗方法。第二个目标是表征免疫反应。

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期刊名称 PLoS Clinical Trials
作者
James S. Cavenaugh; Dorka Awi; Maimuna Mendy; Adrian V. S. Hill; Hilton Whittle; Samuel J. McConkey;
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年(卷),期 2009(6),2
年度 2009
页码 e14626
总页数 14
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专利

1. A randomized trial evaluating the antiviral efficacy of switching from lamivudine plus adefovir to tenofovir disoproxil fumarate monotherapy in lamivudine-resistant chronic hepatitis B patients with undetectable hepatitis B virus DNA [J] . Lee Heon Ju, Kim SangJin, Kweon Young-Oh, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2016,第S1期

机译：一种随机试验，评估从拉米夫定耐慢性乙型肝炎患者中拉米夫鲁德与阿德福韦转换为替莫洛米尔毒性富马特单疗法的抗病毒疗效。
2. Individualization of interferon therapy using serum hepatitis B virus DNA to reduce viral relapse in patients with chronic hepatitis B: a randomized controlled trial. [J] . Chung YH, Song BC, Lee GC, European journal of gastroenterology and hepatology . 2003,第5期

机译：使用血清乙型肝炎病毒DNA降低慢性乙型肝炎患者病毒复发的干扰素治疗的个体化：一项随机对照试验。
3. Hepatitis B virus vaccine in chronic kidney disease: ImprovedTI Hepatitis B virus vaccine in chronic kidney disease: Improved immunogenicity by adjuvants? A meta-analysis of randomized trials [J] . Fabrizi F, Dixit V, Messa P, Vaccine . 2012,第13期

机译：慢性肾脏疾病中的乙肝病毒疫苗：改良的TI慢性肾脏疾病中的乙肝病毒疫苗：佐剂改善的免疫原性？随机试验的荟萃分析
4. Chinese herbal medicine Xiaoyao san (XYS) for chronic hepatitis B (CHB): A meta-analysis of randomized controlled trials [C] . Su Ke-lei, An Zhen-tao, Zhu Fang-shi 2014 IEEE Workshop on Electronics, Computer and Applications . 2014

机译：中药逍遥散（XYS）治疗慢性乙型肝炎（CHB）：一项随机对照试验的荟萃分析
5. Chimeric orthohepadnavirus core particles for oral delivery of vaccines: Part I. Transformation of tobacco plants with a gene encoding a c-terminus truncated hepatitis B virus core protein. Part II. Construction of a woodchuck hepatitis virus core protein-based universal epitope carrier and test expression in Escherichia coli. [D] . Callaghan, Maximilian W. 2001

机译：用于口服递送疫苗的嵌合正丙肝病毒核心颗粒：第一部分。用编码c末端截短的乙型肝炎病毒核心蛋白的基因转化烟草植物。第二部分基于土拨鼠肝炎病毒核心蛋白的通用表位载体的构建和大肠杆菌中的表达测试。
6. Safety and immunogenicity of novel respiratory syncytial virus (RSV) vaccines based on the RSV viral proteins F N and M2-1 encoded by simian adenovirus (PanAd3-RSV) and MVA (MVA-RSV); protocol for an open-label dose-escalation single-centre phase 1 clinical trial in healthy adults [O] . C A Green, E Scarselli, M Voysey, 2015

机译：基于猿猴腺病毒（PanAd3-RSV）和MVA（MVA-RSV）编码的RSV病毒蛋白FN和M2-1的新型呼吸道合胞病毒（RSV）疫苗的安全性和免疫原性；健康成人的开放标签剂量递增单中心1期临床试验方案
7. Partially randomized, non-blinded trial of DNA and MVA therapeutic vaccines based on hepatitis B virus surface protein for chronic HBV infection. [O] . Cavenaugh, JS, Awi, D, Mendy, M, 2011

机译：基于乙型肝炎病毒表面蛋白的DNA和MVA治疗疫苗用于慢性HBV感染的部分随机，非盲试验。

Partially Randomized, Non-Blinded Trial of DNA and MVA TherapeuticVaccines Based on Hepatitis B Virus Surface Protein for Chronic HBVInfection

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