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Analysing Dynamical Behavior of Cellular Networks via Stochastic Bifurcations

机译:通过随机分叉分析细胞网络的动力学行为

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摘要

The dynamical structure of genetic networks determines the occurrence of various biological mechanisms, such as cellular differentiation. However, the question of how cellular diversity evolves in relation to the inherent stochasticity and intercellular communication remains still to be understood. Here, we define a concept of stochastic bifurcations suitable to investigate the dynamical structure of genetic networks, and show that under stochastic influence, the expression of given proteins of interest is defined via the probability distribution of the phase variable, representing one of the genes constituting the system. Moreover, we show that under changing stochastic conditions, the probabilities of expressing certain concentration values are different, leading to different functionality of the cells, and thus to differentiation of the cells in the various types.
机译:遗传网络的动态结构决定了各种生物学机制(例如细胞分化)的发生。但是,细胞多样性如何相对于内在的随机性和细胞间通讯发展的问题仍有待理解。在这里,我们定义了一个随机分支的概念,该概念适用于研究遗传网络的动态结构,并表明在随机影响下,目标蛋白质的表达是通过相变量的概率分布来定义的,代表相变的一种基因系统。此外,我们表明,在随机条件变化的情况下,表达某些浓度值的概率是不同的,从而导致细胞的功能不同,从而导致各种类型的细胞分化。

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