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Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

机译：苯丁酸可抵消志贺氏菌介导的兔肺和肠上皮中Cathelicidin的下调：一种潜在的治疗策略

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BackgroundCathelicidins and defensins are endogenous antimicrobial peptides (AMPs) that are downregulated in the mucosal epithelia of the large intestine in shigellosis. Oral treatment of Shigella infected rabbits with sodium butyrate (NaB) reduces clinical severity and counteracts the downregulation of cathelicidin (CAP-18) in the large intestinal epithelia.

机译：背景Cathelicidins和Defencesins是内源性抗菌肽（AMPs），在志贺菌病的大肠粘膜上皮细胞中被下调。丁酸钠（NaB）口服治疗志贺氏菌感染的兔子可降低临床严重程度，并抵消大肠上皮中cathelicidin（CAP-18）的下调。

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期刊名称 PLoS Clinical Trials
作者
Protim Sarker; Sultan Ahmed; Snigdha Tiash; Rokeya Sultana Rekha; Roger Stromberg; Jan Andersson; Peter Bergman; Gudmundur H. Gudmundsson; Birgitta Agerberth; Rubhana Raqib;
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年(卷),期 2008(6),6
年度 2008
页码 e20637
总页数 10
原文格式 PDF
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专利

1. Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion [J] . Anna K. O. Rode, Martin Kongsbak, Marie M. Hansen, Frontiers in Immunology . 2017,第1期

机译：维生素D抵消树突状细胞结核分枝杆菌诱导的Cathelicidin下调并允许Th1分化和IFNγ分泌
2. Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion [J] . Rode, Anna K. O. Frontiers in Immunology . 2017,第1期

机译：维生素D抵消了分枝杆菌诱导的树突细胞下调的Cathelicidin，并允许Th1分化和IFNγ分泌
3. Pathogenesis of Shigella diarrhea: rabbit intestinal cell microvillus membrane binding site for Shigella toxin. [J] . G Fuchs, M Mobassaleh, A Donohue-Rolfe, Infection and immunity . 1986,第2期

机译：志贺氏菌腹泻的发病机制：兔肠道细胞微绒毛膜结合部位为志贺氏菌毒素。
4. ELECTROPORATION-MEDIATED UPTAKE OF MACROMOLECULES AND RECOVERY OF MODEL INTESTINAL EPITHELIA [C] . E. Ghartey-Tagoe, J. Morgan, A. Neish, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：电动介导的大分子摄取和模型肠上皮细胞的恢复
5. Reduced glucose signaling and downregulation of survivin as potential anticancer therapeutic strategies [D] . Apontes, Pasha 2011

机译：降低葡萄糖信号传导和下调Survivin作为潜在的抗癌治疗策略
6. Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion [O] . Anna K. O. Rode, Martin Kongsbak, Marie M. Hansen, -1

机译：维生素D抵消树突状细胞中结核分枝杆菌诱导的Cathelicidin下调并允许Th1分化和IFNγ分泌
7. Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy [O] . Sarker, Protim, Ahmed, Sultan, Tiash, Snigdha, 2011

机译：苯丁酸可抵消志贺氏菌介导的兔肺和肠上皮中Cathelicidin的下调：一种潜在的治疗策略

Phenylbutyrate Counteracts Shigella Mediated Downregulation of Cathelicidin in Rabbit Lung and Intestinal Epithelia: A Potential Therapeutic Strategy

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