Limits of Calcium Clearance by Plasma Membrane Calcium ATPase in Olfactory Cilia

摘要

BackgroundIn any fine sensory organelle, a small influx of Ca²⁺ can quickly elevate cytoplasmic Ca²⁺. Mechanisms must exist to clear the ciliary Ca²⁺ before it reaches toxic levels. One such organelle has been well studied: the vertebrate olfactory cilium. Recent studies have suggested that clearance from the olfactory cilium is mediated in part by plasma membrane Ca²⁺-ATPase (PMCA).