Freezing of Enkephalinergic Functions by Multiple Noxious Foci: A Source of Pain Sensitization?

摘要

BackgroundThe functional significance of proenkephalin systems in processing pain remains an open question and indeed is puzzling. For example, a noxious mechanical stimulus does not alter the release of Met-enkephalin-like material (MELM) from segments of the spinal cord related to the stimulated area of the body, but does increase its release from other segments.