1952. Evaluation of Relapse and Reinfection Using Whole-Genome Sequencing of Clostridium difficile Isolates From Elderly Patients With C. difficile Infection (CDI) in the EXTEND Randomized Controlled Comparative Study of Extended-Pulsed Fidaxomicin and Vancomycin for the Treatment of CDI

摘要

BackgroundThe EXTEND study demonstrated reduced 90-day recurrence rates for an extended-pulsed regimen of fidaxomicin (EPFX) vs. standard vancomycin (SV) in the treatment of Clostridium difficile infection (CDI): treatment difference −13%, P = 0.00073.¹ Whole-genome sequencing (WGS) is used to differentiate between same-strain relapse and new-strain reinfection of CDI. We used WGS of paired C. difficile samples from patients with CDI recurrence in the EXTEND study to assess EPFX and SV in relation to relapse and reinfection.