1929. Risk of Acute Kidney Injury in Combat-Injured Patients Associated With Concomitant Vancomycin and Extended-Spectrum β-Lactam Antibiotic Use

摘要

BackgroundStudies of vancomycin (VANC) and piperacillin–tazobactam (VPT) induced acute kidney injury (AKI) have included diverse populations obscuring clinical generalizations. To our knowledge, previous studies have omitted combat-related trauma patients despite frequent exposure to broad-spectrum antimicrobials. Our objective was to analyze whether combination therapy with VPT was associated with an increased risk of AKI compared with VANC and other broad-spectrum β-lactam antibiotics (VBL).