2079. The Relation Between Panel Reactive Antibody Assay and Cytomegalovirus Reactivation in Seropositive Solid Organ Transplantation Recipients

摘要

BackgroundCytomegalovirus (CMV) can lead to severe morbidities and mortalities including pneumonia in particular as well as graft dysfunction through indirect immunomodulation in solid-organ transplantation recipients. High degree of HLA mismatch is a well-known risk factor of post-transplant (Tx) CMV reactivation. Recent laboratory advances for evaluating HLA mismatch can measure existence of donor-specific antibodies for single HLA allele; however, there was little evidence whether single panel reactive Ab (PRA) assay could predict CMV reactivation in SOT recipients.