2388. Efficacy of Humanized Cefiderocol Exposures Over 72 Hours Against a Diverse Group of Gram-Negative Isolates in the Neutropenic Murine Thigh Infection Model

摘要

BackgroundPrevious pharmacodynamic (PD) assessments conducted over a 24 hours dosing period have revealed that cefiderocol humanized exposures produced predictable bacterial kill against MDR Gram-negatives with MICs ≤4 mg/L. Our current aim was to evaluate the sustainability of cefiderocol in vivo activity over 72 hours against MDR pathogens. A. baumannii (AB, n = 4), P. aeruginosa (PSA, n = 2), K. pneumoniae (KP, n = 4) and E. coli (EC, n = 2) displaying cefiderocol MICs of 0.5–16 mg/L were used in the neutropenic murine thigh model.