396. Aminoglycoside Acute Kidney Injury (AKI) Following the Implantation of Tobramycin Loaded Polymethylmethacrylate (PMMA) Cement and Calcium Sulfate (CaSO4) Beads for the Treatment of Periprosthetic Joint Infection (PJI)

摘要

BackgroundAntibiotic loaded bone cement (ALBC) in PMMA, generally with tobramycin and vancomycin (TV) is commonly used for the treatment of PJI. CaSO4 beads, loaded with TV is biodegradable and can be used alone or in combination with PMMA. Identification of AKI following documentation of sustained supra-therapeutic tobramycin levels a patient with chronic PJI treated with ALBC (both PMMA + CaSO4) prompted the development of guidelines to mitigate risk of AKI in patients treated with ALBC. Although AKI may be enhanced with vancomycin, case reports with TV in PMMA implicate tobramycin. We provide data in a cohort of patients treated for PJI using PMMA or PMMA + CaSO4.