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Cancer risks by gene age and gender in 6350 carriers ofpathogenic mismatch repair variants: findings from the Prospective Lynch SyndromeDatabase

机译：6350名携带者的按基因年龄和性别分类的癌症风险致病性错配修复变异体：前瞻性林奇综合症的发现数据库

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Cumulative risk of any cancer: original cohort, validation cohort; and cumulativerisk of colorectal cancer (CRC): original cohort and validation cohort. There were no significantdifferences between original and validation cohorts. Center valuesare means and error bars show 95% confidence intervals(CIs).

机译：任何癌症的累积风险：原始队列，验证队列;和累积的结直肠癌的风险：原始队列和验证队列。没有重大意义原始队列和验证队列之间的差异。中心值是平均值，误差线显示95％的置信区间（CI）。

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期刊名称 NPG Open Access
作者
Mev Dominguez-Valentin; Julian R. Sampson; Toni T. Seppälä; Sanne W. ten Broeke; John-Paul Plazzer; Sigve Nakken; Christoph Engel; Stefan Aretz; Mark A. Jenkins; Lone Sunde; Inge Bernstein; Gabriel Capella; Francesc Balaguer; Huw Thomas; D. Gareth Evans; John Burn; Marc Greenblatt; Eivind Hovig; Wouter H. de Vos tot Nederveen Cappel; Rolf H. Sijmons; Lucio Bertario; Maria Grazia Tibiletti; Giulia Martina Cavestro; Annika Lindblom; Adriana Della Valle; Francisco Lopez-Köstner; Nathan Gluck; Lior H. Katz; Karl Heinimann; Carlos A. Vaccaro; Reinhard Büttner; Heike Görgens; Elke Holinski-Feder; Monika Morak; Stefanie Holzapfel; Robert Hüneburg; Magnus von Knebel Doeberitz; Markus Loeffler; Nils Rahner; Hans K. Schackert; Verena Steinke-Lange; Wolff Schmiegel; Deepak Vangala; Kirsi Pylvänäinen; Laura Renkonen-Sinisalo; John L. Hopper; Aung Ko Win; Robert W. Haile; Noralane M. Lindor; Steven Gallinger; Loïc Le Marchand; Polly A. Newcomb; Jane C. Figueiredo; Stephen N. Thibodeau; Karin Wadt; Christina Therkildsen; Henrik Okkels; Zohreh Ketabi; Leticia Moreira; Ariadna Sánchez; Miquel Serra-Burriel; Marta Pineda; Matilde Navarro; Ignacio Blanco; Kate Green; Fiona Lalloo; Emma J. Crosbie; James Hill; Oliver G. Denton; Ian M. Frayling; Einar Andreas Rødland; Hans Vasen; Miriam Mints; Florencia Neffa; Patricia Esperon; Karin Alvarez; Revital Kariv; Guy Rosner; Tamara Alejandra Pinero; María Laura Gonzalez; Pablo Kalfayan; Douglas Tjandra; Ingrid M. Winship; Finlay Macrae; Gabriela Möslein; Jukka-Pekka Mecklin; Maartje Nielsen; Pål Møller;
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年(卷),期 -1(22),1
年度 -1
页码 -1
总页数 11
原文格式 PDF
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关键词
Lynch syndrome;

机译：林奇综合症;

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专利

1. Response to Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [J] . Genetics in medicine . 2020,第4期

机译：响应响应Dominguez-Valentin M等人。 2019年：癌症风险由基因，年龄和性别在6350年的致病失配修复变体：从前瞻性林奇综合征数据库的调查结果
2. Response to Dominguez-Valentin M et al. 2019: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [J] . Genetics in medicine . 2020,第4期

机译：对Dominguez-Valentin M等人的回应。 2019年：癌症风险由基因，年龄和性别在6350年的致病失配修复变体：从前瞻性林奇综合征数据库的调查结果
3. Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [J] . Dominguez-Valentin Mev, Sampson Julian R., Seppala Toni T., Genetics in medicine . 2020,第1期

机译：癌症风险由基因，年龄和性别在致病性失配修复变体的6350次载体中：从前瞻性林奇综合征数据库的调查结果
4. The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations [C] . Janet Hall, Virginie Marcel, Celeste Bolin Biochemical Society Symposium . 2009

机译：DNA修复和细胞周期基因中序列变体在具有癌症风险的关联：基因型 - 表型相关性
5. Evaluation of the accuracy of quantitative models in predicting Lynch syndrome (hereditary nonpolyposis colorectal cancer with defective DNA mismatch repair) mutations in a population-based sample of early-onset colorectal cancer patients [D] . Carpiniello, Lauren 2007

机译：在以人群为基础的早发性大肠癌患者样本中预测定量模型预测Lynch综合征（遗传性非息肉病性大肠直肠癌，DNA失配修复缺陷）的准确性
6. Original article: Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database [O] . Pål Møller, Toni T Seppälä, Inge Bernstein, -1

机译：原始文章：高达75岁的按基因和性别分类的path_MMR携带者中path_MMR携带者的癌症风险和生存率：前瞻性林奇综合症数据库的报告
7. Correction: Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database [O] . Mev Dominguez-Valentin, Julian R. Sampson, Toni T. Seppälä, 2020

机译：校正：癌症风险基因，年龄和性别在6350个携带匹配变体的载体中：从前瞻性林奇综合征数据库中的调查结果

Cancer risks by gene age and gender in 6350 carriers ofpathogenic mismatch repair variants: findings from the Prospective Lynch SyndromeDatabase

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