Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

摘要

BackgroundPorphyrin TMPyP4 (P4) and its C14H28-alkyl derivative (C14) are G-quadruplex binders and singlet oxygen (¹O2) generators. In contrast, TMPyP2 (P2) produces ¹O2 but it is not a G-quadruplex binder. As their photosensitizing activity is currently undefined, we report in this study their efficacy against a melanoma skin tumour and describe an in vitro mechanistic study which gives insights into their anticancer activity.