Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor κB Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-κB Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages

机译：新藤黄酸通过抑制小鼠骨髓源性单核细胞/巨噬细胞的JNK和NF-κB途径抑制核因子κB配体（RANKL）诱导破骨细胞的受体激活剂。

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BackgroundNeogambogic acid (NGA) is used in traditional Chinese medicine. The aim of this study was to investigate the effects of NGA on gene signaling pathways involved in osteoclastogenesis in mouse bone marrow-derived monocyte/macrophages (BMMs) and on bone resorption in vitro.

机译：背景新竹新霉素（NGA）用于传统中药。这项研究的目的是研究NGA对小鼠骨髓源性单核细胞/巨噬细胞（BMM）的破骨细胞生成相关基因信号通路以及体外骨吸收的影响。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Gu Jin; Fang-Fang Wang; Tao Li; Dong-Dong Jia; Yong Shen; Hai-Chao Xu;
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作者单位

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年(卷),期 1923(24),
年度 1923
页码 2569–2577
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
Garcinia, MAP Kinase Signaling System, NF-kappa B, Osteoclasts, RANK Ligand;

机译：藤黄;MAP激酶信号传导系统;NF-κB;破骨细胞;RANK配体;

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专利

1. Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca 2+-nuclear factor of activated T-cells cytoplasmic 1 signaling pathways [J] . WuX., LiZ., YangZ., Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research . 2012,第6期

机译：咖啡酸3,4-二羟基苯乙基酯通过抑制丝裂原激活的蛋白激酶/激活蛋白1和激活T的Ca 2+核因子，抑制NF-κB配体诱导的破骨细胞生成的受体激活剂并防止卵巢切除术引起的骨丢失。细胞的细胞质1信号通路
2. Arctigenin suppresses receptor activator of nuclear factor κb ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages [J] . KimA.-R., KimH.S., LeeJ.M., European Journal of Pharmacology: An International Journal . 2012,第1a3期

机译：Arctigenin抑制骨髓源巨噬细胞中核因子κb配体（RANKL）介导的破骨细胞分化的受体激活剂
3. Pyridone 6, A Pan-Janus-Activated Kinase Inhibitor, Suppresses Osteoclast Formation and Bone Resorption through Down-Regulation of Receptor Activator of Nuclear Factor-kappa B (NF-kappa B) Ligand (RANKL)-Induced c-Fos and Nuclear Factor of Activated T Cells (NFAT) c1 Expression [J] . Kwak HB, Kim HS, Lee MS, Biological & pharmaceutical bulletin . 2009,第1期

机译：吡啶酮6，泛janus-活化的激酶抑制剂，通过核因子-kappa（nf-κB）配体（RANKL）诱导的C-FOS和核因子的受体激活剂的下调来抑制破骨细胞形成和骨吸收活化T细胞（NFAT）C1表达
4. Orthopedic Implant Particle-Induced Tumor Necrosis Factor-a Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells [C] . HIROSHI MINEMATSU, MIKE J. SHIN, AYSE B. CELIL AYDEMIR, Conference on Skeletal Biology and Medicine . 2007

机译：矫形植入物颗粒诱导的肿瘤坏死因子 - 巨噬细胞单核细胞谱系细胞的产生是由活化T细胞的核因子介导的
5. Tumor necrosis factor-alpha (TNFalpha) and receptor activator of NFkappaB ligand (RANKL) regulate osteoclast activity: Potential therapeutic targets in wear debris-induced osteolysis. [D] . Flick, Lisa Marie. 2002

机译：肿瘤坏死因子-α（TNFalpha）和NFkappaB配体的受体激活剂（RANKL）调节破骨细胞活性：磨损碎片诱导的骨溶解的潜在治疗靶标。
6. α-Linolenic Acid Inhibits Receptor Activator of NF-κB Ligand Induced (RANKL-Induced) Osteoclastogenesis and Prevents Inflammatory Bone Loss via Downregulation of Nuclear Factor-KappaB-Inducible Nitric Oxide Synthases (NF-κB-iNOS) Signaling Pathways [O] . Jiefu Song, Zhizhen Jing, Wei Hu, 2017

机译：α-亚麻酸抑制NF-κB配体诱导（RANKL诱导）破骨细胞生成的受体激活剂并通过下调核因子-κB诱导型一氧化氮合酶（NF-κB-iNOS）信号传导途径防止炎症性骨丢失。
7. Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor κB Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-κB Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages [O] . Gu Jin, Fang-Fang Wang, Tao Li, 2018

机译：Neogampogic酸抑制了核因子κB配体（RANKL）的受体活化剂，通过抑制小鼠骨髓衍生的单核细胞/巨噬细胞的JNK和NF-κB途径抑制了骨髓细胞发生

Neogambogic Acid Suppresses Receptor Activator of Nuclear Factor κB Ligand (RANKL)-Induced Osteoclastogenesis by Inhibiting the JNK and NF-κB Pathways in Mouse Bone Marrow-Derived Monocyte/Macrophages

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