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Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake

机译：评价药物对未麻醉和未刺激大鼠的脑血流和葡萄糖摄取的影响：使用自由移动装置可在PET / SPECT示踪剂注射和摄取期间使大鼠保持自由

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摘要

ObjectivesThe purpose of this study is the development of novel fluorine-18-fluorodeoxyglucose (¹⁸F-FDG)-PET and ^99mTc-hexamethylpropylene amine oxime (HMPAO) SPECT methods with free-moving apparatus on conscious rats to investigate brain activity without the effects of anesthesia and tactual stimulation. We also assessed the sensitivity of the experimental system by an intervention study using fluoxetine as a reference drug.

机译：目的本研究的目的是开发新的氟18-氟脱氧葡萄糖（^{18 F-FDG）-PET和^{99m Tc-六甲基丙烯胺肟（HMPAO）SPECT方法在意识大鼠上使用自由移动装置来研究大脑活动，而没有麻醉和触觉刺激的影响。我们还通过使用氟西汀作为参考药物的干预研究评估了实验系统的敏感性。}}

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期刊名称 Lippincott Williams Wilkins Open Access
作者
Taku Sugita; Yusuke Kondo; Seigo Ishino; Ikuo Mori; Takashi Horiguchi; Mikako Ogawa; Yasuhiro Magata;
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作者单位

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年(卷),期 -1(39),8
年度 -1
页码 753–760
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
conscious sup18/supF-FDG-PET free moving nonanesthesia rat sup99m/supTc-HMPAO;

机译：有意识的;sup 18 / sup F-FDG-PET;自由移动;非麻醉;大鼠;sup 99m / sup Tc-HMPAO;

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专利

1. Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake [J] . Sugita Taku, Kondo Yusuke, Ishino Seigo, Nuclear Medicine Communications . 2018,第8期

机译：对未麻醉和未刺激的大鼠脑血流和葡萄糖摄取的药物影响评价：自由移动设备的应用，使得在PET / SPECT示踪剂注射和摄取期间保持大鼠的大鼠
2. Intracerebral administration of protein kinase A or cAMP response element-binding protein antisense oligonucleotide can modulate amphetamine-mediated appetite suppression in free-moving rats. [J] . Hsieh YS, Yang SF, Kuo DY American Journal of Physiology . 2007,第1期

机译：脑内施用蛋白激酶A或cAMP反应元件结合蛋白反义寡核苷酸可调节自由移动大鼠的苯丙胺介导的食欲抑制。
3. Intracerebral administration of protein kinase A or cAMP response element-binding protein antisense oligonucleotide can modulate amphetamine-mediated appetite suppression in free-moving rats. [J] . Hsieh YS, Yang SF, Kuo DY American Journal of Physiology . 2007,第1期

机译：脑内施用蛋白激酶A或cAMP反应元件结合蛋白反义寡核苷酸可调节自由移动大鼠的苯丙胺介导的食欲抑制。
4. Non invasive optical monitoring of rat brain and effects of the injection of tracers for blood flow measurements [C] . R. Sablong, E. Grillon, O. Hugon, European Conference on Biomedical Optics . 2001

机译：大鼠大脑的非侵入光学监测和喷射示踪剂的血流测量效果
5. THEORY OF INTERACTION OF DRUGS AND OTHER MOLECULAR SPECIES WITH BLOOD-BRAIN BARRIER AND EVALUATION OF BRAIN-UPTAKE INDEX INCLUDING COOPERATIVE EFFECTS AND PHASE-TRANSITION [D] . VIMAL, RAM LAKHAN PANDEY 1983

机译：药物与其他分子与血脑屏障相互作用的理论以及包括协同效应和相变的脑吸收指数的评估
6. Regional cerebral effects of ketone body infusion with 3-hydroxybutyrate in humans: Reduced glucose uptake, unchanged oxygen consumption and increased blood flow by positron emission tomography. A randomized, controlled trial [O] . Mads Svart, Lars C. Gormsen, Jakob Hansen, 2012

机译：酮体中3-羟基丁酸酯输注对人体的区域性脑效应：通过正电子发射断层扫描术，减少了葡萄糖的摄取，不变的耗氧量和血流量的增加。随机对照试验
7. Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats [O] . Taku Sugita, Yusuke Kondo, Seigo Ishino, 2018

机译：对脑血流量和葡萄糖摄取的药物作用评价，在未麻醉和未刺激的大鼠中的葡萄糖摄取
8. Design and Evaluation of Radiotracers for Determination of Regional Cerebral Blood Flow with PET [R] . Lambrecht, R. M., Duncan, C. C., Shiue, C. Y. 1982

机译：用放射性示踪剂测定局部脑血流量的设计与评价

Evaluation of drug effects on cerebral blood flow and glucose uptake in un-anesthetized and un-stimulated rats: application of free-moving apparatus enabling to keep rats free during PET/SPECT tracer injection and uptake

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