A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients

机译：darunavir / cobicistat / emtricitabine / tenofovir alafenamide在未经治疗的HIV-1患者中的第48周随机3期试验

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摘要

Objectives:To investigate efficacy and safety of a single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) 800/150/200/10 mg vs. darunavir/cobicistat plus emtricitabine/tenofovir disoproxyl fumarate (TDF) (control) in antiretroviral-treatment-naive, HIV-1-infected adults.

机译：目的：研究达那那韦/考比西他/恩曲他滨/替诺福韦阿拉芬酰胺（D / C / F / TAF）800/150/200 /10μmg相对于达那那韦/考比司他联合恩曲他滨/替诺福韦富马酸替诺福韦单片剂方案的疗效和安全性（TDF）（对照）用于未接受过抗逆转录病毒治疗的HIV-1感染的成年人。

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期刊名称 Lippincott Williams Wilkins Open Access
作者
Joseph J. Eron; Chloe Orkin; Joel Gallant; Jean-Michel Molina; Eugenia Negredo; Andrea Antinori; Anthony Mills; Jacques Reynes; Erika Van Landuyt; Erkki Lathouwers; Veerle Hufkens; John Jezorwski; Simon Vanveggel; Magda Opsomer;
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年(卷),期 -1(32),11
年度 -1
页码 1431–1442
总页数 12
原文格式 PDF
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关键词
darunavir/cobicistat/emtricitabine/tenofovir alafenamide efficacy once daily safety single-tablet HIV-1 regimen;

机译：darunavir / cobicistat / emtricitabine / tenofovir alafenamide;疗效;每天一次;安全性;单片HIV-1方案;

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专利

1. A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients [J] . Eron Joseph J., Orkin Chloe, Gallant Joel, AIDS . 2018,第11期

机译：一周为期48次随机相3阶段试验Darunavir / Cobicistat / Emtricitabine / Tenofovir Alafenainide治疗 - 幼稚HIV-1患者
2. Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1 [J] . Eron Joseph J., Orkin Chloe, Cunningham Douglas, Antiviral Research . 2019,第期

机译：第9周的疗效和安全结果3阶段，随机祖母绿试验评估从增强蛋白酶抑制剂的切换加上Emtricitabine / Tenofovir Disoproxil富马酸莫霉素治疗达伦韦/钴/ Emtricitabine / Tenofovir Alafenaine的单片体方案（D / C / F / TAF）在治疗经验丰富的病毒学 - 被抑制的成年人与HIV-1一起生活
3. Week 96 results of a phase 3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients [J] . AIDS . 2020,第5期

机译：第96周96阶段3阶段试验Darunavir / Cobicistat / Emtricisabine / Tenofovir AlafenaMide治疗 - 幼稚HIV-1患者
4. Randomized, sham-controlled trial based on transcranial direct current stimulation and wrist robot-assisted integrated treatment on subacute stroke patients: Intermediate results [C] . Stefano Mazzoleni, Vi Do Tran, Laura Iardella, 2017 International Conference on Rehabilitation Robotics . 2017

机译：基于经颅直流电刺激和腕机器人辅助综合治疗的亚急性中风患者的随机，假对照试验：中间结果
5. Cost effectiveness analysis of abacavir/lamivudine versus tenofovir/emtricitabine combination therapy as part of highly active antiretroviral therapy in treatment naive HIV-infected patients. [D] . Giguere, Pierre. 2010

机译：阿巴卡韦/拉米夫定与替诺福韦/恩曲他滨联合疗法作为高活性抗逆转录病毒疗法治疗未受HIV感染的患者的成本效益分析。
6. 1768. Efficacy and Safety of Switching From Boosted-Protease Inhibitors (bPI) Plus Emtricitabine/Tenofovir Disoproxil Fumarate (F/TDF) Regimens to the Once Daily (QD) Single-Tablet Regimen (STR) of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) in Virologically Suppressed HIV-1-Infected Adults: Week 96 Results of the Phase 3 Randomized Non-Inferiority EMERALD Trial [O] . Joseph Eron, Chloe Orkin, Douglas Cunningham, -1

机译：1768.从强化蛋白酶抑制剂（bPI）加上恩曲他滨/替诺福韦富马酸二氯吡呋酯（F / TDF）方案改为每日一次（QD）单药方案（STR）Darunavir / Cobicistat / Emtricitabine / Tenofovir的功效和安全性在病毒学上被抑制HIV-1感染的成年人中Alafenamide（D / C / F / TAF）：第3周随机非自卑性EMERALD试验的第96周结果
7. A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients [O] . Joseph J. Eron, Chloe Orkin, Joel Gallant, 2018

机译：一周为期48次随机相3试验Darunavir / Cobicistat / Emtricisabine / Tenofovir Alafenide治疗 - 幼稚HIV-1患者

A week-48 randomized phase-3 trial of darunavir/cobicistat/emtricitabine/tenofovir alafenamide in treatment-naive HIV-1 patients

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