The levels of urine CTX-II C2C and PYD in children patients with Kashin-Beck disease in Qinghai Province of China

摘要

BackgroundKashin-Beck disease (KBD) is an endemic and chronic osteoarthropathy. At present, the diagnosis of KBD mainly depends on the X-ray examination and which could not reflect early damage of cartilage sensitively. So, the aim of this study was to find effective and sensitive biomarkers for early diagnosis of pediatric KBD.