Statistical parametric mapping with 18F-dopa PETshows bilaterally reduced striatal and nigral dopaminergic function inearly Parkinsons disease

摘要

OBJECTIVE—To apply statistical parametric mapping to ¹⁸F-dopa PET data sets, to examine the regional distribution of changes in dopaminergic metabolism in early asymmetric Parkinson's disease.
METHODS—Thirteen normal volunteers (age 57.7 (SD 16.5) years; four women, nine men ) and six patients (age 50.3 (SD 13.5) years; three women, three men) with asymmetric (right sided) Parkinson's disease were studied. Images from each dynamic dopa PET dataset were aligned and parametric images of ¹⁸F-dopa influx (Ki) were created for each subject. The Ki images were transformed into standard stereotactic space. The Ki values of the caudate and putamen on spatially normalised images were compared with the Ki values before normalisation. The application of statistical parametric mapping (SPM) allowed statistical comparison of regional Ki values on a voxel by voxel basis between healthy volunteers and patients with Parkinson's disease.
RESULTS—There was a strong correlation between the Ki values before and after spatial normalisation (r=0.898, p=0.0001). Significant decreases in the Ki values were found for the Parkinson's desease group throughout the entire left putamen (p< 0.001) andfocally in the dorsal right putamen (p< 0.001). Decreased Ki valueswere also shown bilaterally in the substantia nigra (p< 0.01).
CONCLUSION—Using (SPM)and ¹⁸F-dopa PET, reductions in both striatal and nigralbrain dopaminergic function could be demonstrated in early Parkinson's disease.