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Cracking up: symmetry breaking in cellular systems

机译:破解:蜂窝系统中的对称性破坏

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摘要

The shape of animal cells is, to a large extent, determined by the cortical actin network that underlies the cell membrane. Because of the presence of myosin motors, the actin cortex is under tension, and local relaxation of this tension can result in cortical flows that lead to deformation and polarization of the cell. Cortex relaxation is often regulated by polarizing signals, but the cortex can also rupture and relax spontaneously. A similar tension-induced polarization is observed in actin gels growing around beads, and we propose that a common mechanism governs actin gel rupture in both systems.
机译:动物细胞的形状在很大程度上取决于细胞膜下的皮质肌动蛋白网络。由于肌球蛋白马达的存在,肌动蛋白皮层处于张力下,这种张力的局部松弛会导致皮质流动,从而导致细胞变形和极化。皮层松弛通常通过极化信号来调节,但是皮层也可以自发破裂和松弛。在珠子周围生长的肌动蛋白凝胶中观察到类似的张力诱导的极化,我们提出了在两种系统中控制肌动蛋白凝胶破裂的共同机制。

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