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The Drosophila l(1)zw10 gene product required for accurate mitotic chromosome segregation is redistributed at anaphase onset

机译:果蝇l(1)zw10基因产物准确的有丝分裂染色体分离所需在后期开始时重新分配。

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摘要

Mutations in the gene l(1)zw10 disrupt the accuracy of chromosome segregation in a variety of cell types during the course of Drosophila development. Cytological analysis of mutant larval brain neuroblasts shows very high levels of aneuploid cells. Many anaphase figures are aberrant, the most frequent abnormality being the presence of lagging chromosomes that remain in the vicinity of the metaphase plate when the other chromosomes have migrated toward the spindle poles. Finally, the centromeric connection between sister chromatids in mutant neuroblasts treated with colchicine often appears to be broken, in contrast with similarly treated control neuroblasts. The 85-kD protein encoded by the l(1)zw10 locus displays a dynamic pattern of localization in the course of the embryonic cell cycle. It is excluded from the nuclei during interphase, but migrates into the nuclear zone during prometaphase. At metaphase, the zw10 antigen is found in a novel filamentous structure that may be specifically associated with kinetochore microtubules. Upon anaphase onset, there is an extremely rapid redistribution of the zw10 protein to a location at or near the kinetochores of the separating chromosomes.
机译:在果蝇发育过程中,基因l(1)zw10中的突变破坏了各种细胞类型中染色体分离的准确性。突变幼虫脑神经母细胞的细胞学分析显示非整倍体细胞水平很高。许多后期阶段的数字都是异常的,最常见的异常情况是当其他染色体向纺锤极迁移时,滞留染色体的存在会保留在中期板附近。最后,与相似处理的对照成神经细胞相比,秋水仙碱处理的突变成神经细胞中姐妹染色单体之间的着丝粒连接似乎被破坏。 l(1)zw10基因座编码的85 kD蛋白在胚胎细胞周期过程中显示出动态的定位模式。在相间期它被排除在原子核外,而在中期前期迁移到核区。在中期,在新型丝状结构中发现了zw10抗原,该结构可能与线粒体微管特异性结合。在后期发病时,zw10蛋白非常迅速地重新分布到分离染色体的动粒体处或附近。

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