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首页> 美国卫生研究院文献>Iranian Journal of Pharmaceutical Research : IJPR >The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients
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The Effects of Berberis vulgaris Fruit Extract on Serum Lipoproteins, apoB, apoA-I, Homocysteine, Glycemic Control and Total Antioxidant Capacity in Type 2 Diabetic Patients

机译：小Ber果实提取物对2型糖尿病患者血清脂蛋白，apoB，apoA-I，同型半胱氨酸，血糖控制和总抗氧化能力的影响

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Type 2 diabetes is a well-known endocrine and metabolic disorder which has reached epidemic proportions worldwide and represents a serious public health concern. Hyperglycemia and dyslipidemia are two major abnormalities which are major cardiovascular risk factors. Berberine is a major alkaloid in Berberis vulgaris fruit extract (BVFE) which have important role in regulation of serum glucose and fat metabolism in-vivo and in-vitro but its role in type 2 diabetes have not been extensively examined.The aim of this study was the effect of BVFE on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. In a double-blind randomised clinical trial, 31 diabetic patients were randomly assigned to 3 g/d BVFE or placebo for 3 months. Serum glucose, lipoproteins, apoB, apoA-I, insulin, homocysteine and HbA1c were measured at the baseline and also at the end of the 3rd month.At the beginning and end of 1st, 2nd and 3rd months, a 24-h dietary recall questionnaire about each patients was completed. Data were analyzed by SPSS version 16.There were significant decreases in serum TG, TC, LDL-c, apo B, glucose, and insulin and also a significant increase in TAC at the end of the study in BVFE group compared to the control group (p = 0.001, p = 0.001, p = 0.001, p = 0.001, p = 0.002, p = 0.01 and p = 0.0001 respectively).There were significant differences in serum TG (p = 0.0001), TC (p = 0.001), LDL-c (p = 0.001), apoB (p = 0.001), glucose (p = 0.002), insulin (p = 0.01), TAC (p = 0.005), and insulin resistance (p = 0.01) between the two groups at the end of the study; but homocysteine, HbA1c and HDL-c showed no significant changes between the two groups at the end of study.The intake of 3 g/d BVFE for 3 months may have benefical effects on lipoproteins, apoproteins, glycemic control and TAC in type 2 diabetic patients.
机译：2型糖尿病是一种众所周知的内分泌和代谢紊乱，已在全球范围内流行，代表了严重的公共卫生问题。高血糖和血脂异常是两个主要异常，它们是主要的心血管危险因素。小ber碱是小Ber果实提取物（BVFE）中的主要生物碱，在体内和体外调节血糖和脂肪代谢中起重要作用，但尚未广泛研究其在2型糖尿病中的作用。本研究的目的是BVFE对2型糖尿病患者血清脂蛋白，apoB，apoA-I，高半胱氨酸，血糖控制和总抗氧化能力的影响。在一项双盲随机临床试验中，将31名糖尿病患者随机分配至3 g / d BVFE或安慰剂治疗3个月。在基线和第三个月末测量血清葡萄糖，脂蛋白，apoB，apoA-I，胰岛素，高半胱氨酸和HbA1c。在第一个水平的开始和结束时，2 nd 和3 rd 个月，完成了有关每位患者的24小时饮食回想问卷。通过SPSS版本16分析数据。与对照组相比，BVFE组在研究结束时血清TG，TC，LDL-c，apo B，葡萄糖和胰岛素显着降低，TAC显着增加。 （p = 0.001，p = 0.001，p = 0.001，p = 0.001，p = 0.002，p = 0.01和p = 0.0001）。血清TG（p = 0.0001），TC（p = 0.001）有显着差异。 ，两组之间的LDL-c（p = 0.001），apoB（p = 0.001），葡萄糖（p = 0.002），胰岛素（p = 0.01），TAC（p = 0.005）和胰岛素抵抗（p = 0.01）在研究结束时；但是在研究结束时，两组之间的同型半胱氨酸，HbA1c和HDL-c没有显着变化。连续3个月摄入3 g / d BVFE可能对2型糖尿病患者的脂蛋白，载脂蛋白，血糖控制和TAC有益耐心。

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