Abnormal urinary findings, such as sterile pyuria, proteinuria, and microscopic hematuria, are often seen in the acute phase of Kawasaki disease (KD). We investigated the potential significance of urinary lactate dehydrogenase (U-LDH) activity and its isozyme patterns in KD. Total U-LDH activity and its isozymes (U-LDH1-5) levels were compared among 120 patients with KD, 18 patients with viral infection (VI), and 43 patients with upper urinary tract infection (UTI) and additionally compared between intravenous immunoglobulin (IVIG) responders (n = 89) and nonresponders (n = 31) with KD. Total U-LDH activity was higher in KD (35.4 ± 4.8 IU/L, P < 0.05) and UTI patients (66.0 ± 8.0 IU/L, P < 0.01) than in VI patients (17.0 ± 6.2 IU/L). In the isozyme pattern analysis, KD patients had high levels of U-LDH1 and U-LDH2, while UTI patients had high levels of U-LDH3, U-LDH4, and U-LDH5. Furthermore, IVIG nonresponders of KD had significantly higher levels of total U-LDH activity (45.1 ± 4.7 IU/L, P < 0.05), especially U-LDH1 and U-LDH2 (P < 0.05), than IVIG responders (32.0 ± 2.8 IU/L). KD patients have increased levels of total U-LDH activity, especially U-LDH-1 and U-LDH2, indicating a unique pattern of U-LDH isozymes different from that in UTI patients.
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机译：在川崎病（KD）的急性期中经常会出现异常的尿液发现，例如不育性脓尿，蛋白尿和镜下血尿。我们调查了尿中乳酸脱氢酶（U-LDH）活性及其在KD中的同工酶模式的潜在意义。比较120例KD患者，18例病毒感染（VI）和43例上尿路感染（UTI）患者的总U-LDH活性及其同工酶（U-LDH1-5）水平，并比较静脉内免疫球蛋白（IVIG）有KD的响应者（n = 89）和无响应者（n = 31）。 KD（35.4±4.8 IU / L，P <0.05）和UTI患者（66.0±8.0 IU / L，P <0.01）的总U-LDH活性高于VI患者（17.0±6.2 IU / L）。在同工酶模式分析中，KD患者的U-LDH1和U-LDH2水平较高，而UTI患者的U-LDH3，U-LDH4和U-LDH5水平较高。此外，与IVIG应答者相比，IVIG无应答者KD的总U-LDH活性水平显着更高（45.1±4.7 IU / L，P <0.05），尤其是U-LDH1和U-LDH2（P <0.05）。 IU / L）。 KD患者的总U-LDH活性水平升高，尤其是U-LDH-1和U-LDH2，表明U-LDH同工酶的独特模式不同于UTI患者。
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