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Rituximab levels are associated with the B cell homeostasis but not with the clinical response in patients with rheumatoid arthritis

机译：在类风湿关节炎患者中利妥昔单抗水平与B细胞稳态有关但与临床反应无关

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摘要

ObjectiveTo study the levels of rituximab (RTX) and anti-RTX antibodies (ARAs) in patients with rheumatoid arthritis (RA) at 30, 90, and 180 days after the first infusion, in relation to clinical and serological parameters and B cell homeostasis.

机译：目的研究类风湿关节炎（RA）首次输注后30、90和180天的利妥昔单抗（RTX）和抗RTX抗体（ARAs）水平与临床和血清学参数以及B细胞稳态的关系。

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期刊名称 European Journal of Rheumatology
作者
Cèsar Díaz-Torné; Maria Àngels Ortiz; Mónica Sarmiento; César Díaz-López; Hèctor Corominas; Jordi Casademont; Silvia Vidal;
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作者单位

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年(卷),期 2019(6),2
年度 2019
页码 81–84
总页数 4
原文格式 PDF
正文语种
中图分类免疫性疾病;
关键词
Rheumatoid arthritis rituximab B cells;

机译：类风湿关节炎;利妥昔单抗;B细胞;
入库时间 2022-08-17 12:13:01

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专利

1. Rituximab pharmacokinetics in patients with rheumatoid arthritis: B-cell levels do not correlate with clinical response. [J] . Breedveld F, Agarwal S, Yin M, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2007,第9期

机译：类风湿关节炎患者的利妥昔单抗药代动力学：B细胞水平与临床反应无关。
2. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response [J] . Magda Nakou, Georgios Katsikas, Prodromos Sidiropoulos, Arthritis Research . 2009,第4期

机译：利妥昔单抗治疗可减少类风湿关节炎患者外周血和骨髓中活化的B细胞：记忆B细胞耗竭与临床反应相关
3. Baseline serum immunoglobulin levels in patients with rheumatoid arthritis: Relationships with clinical parameters and with B-cell dynamics following rituximab [J] . delaTorreI., LeandroM.J., EdwardsJ.C.W., Clinical and experimental rheumatology . 2012,第4期

机译：类风湿关节炎患者基线血清免疫球蛋白水平：与利妥昔单抗后临床参数和B细胞动态的关系
4. Identification of candidate genes for Rituximab response in rheumatoid arthritis with weighted gene co-expression network analysis [C] . Guiying Dong, Zhi-Ping Liu, Rui Gao, Chinese Automation Congress . 2017

机译：用加权基因共表达网络分析鉴定类风湿关节炎中利妥昔单抗反应的候选基因
5. Clinical studies of immunomodulatory activities of Yunzhi -Danshen in breast cancer and nasopharyngeal carcinoma patients, and Lingzhi-San Miao San in rheumatoid arthritis patients. [D] . Bao, Yixi. 2005

机译：云芝丹参对乳腺癌和鼻咽癌患者及类风湿关节炎灵芝三妙散的免疫调节活性的临床研究。
6. Rituximab therapy reduces activated B cells in both the peripheral blood and bone marrow of patients with rheumatoid arthritis: depletion of memory B cells correlates with clinical response [O] . Magda Nakou, Georgios Katsikas, Prodromos Sidiropoulos, 2009

机译：利妥昔单抗治疗可减少类风湿关节炎患者外周血和骨髓中活化的B细胞：记忆B细胞耗竭与临床反应相关
7. Rituximab levels are associated with the B cell homeostasis but not with the clinical response in patients with rheumatoid arthritis [O] . Cèsar Díaz‐Torné, Maria Àngels Ortiz, Mónica Sarmiento, 2019

机译：Rituximab水平与B细胞稳态相关，但不是类风湿性关节炎患者的临床反应

Rituximab levels are associated with the B cell homeostasis but not with the clinical response in patients with rheumatoid arthritis

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