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Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction

机译：锰在神经元SK-N-MC细胞系上引起的细胞凋亡：内质网（ER）应激和线粒体功能障碍

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ObjectivesManganese chloride (MnCl2) is one of heavy metals for causing neurogenerative dysfunction like Manganism. The purpose of this study was to determine the acute toxicity of MnCl2 using different times and various concentrations including whether manganese toxicity may involve in two intrinsic pathways, endoplasmic reticulum (ER) stress and mitochondria dysfunction and lead to neuronal apoptosis mediated by organelle disorders in neuroblastoma cell line SK-N-MC.

机译：目的氯化锰（MnCl2）是引起锰等神经发生功能障碍的重金属之一。这项研究的目的是使用不同的时间和不同的浓度来确定MnCl2的急性毒性，包括锰毒性是否可能涉及两个内在途径，内质网（ER）应激和线粒体功能障碍以及导致神经母细胞瘤细胞器疾病介导的神经元凋亡。细胞系SK-N-MC。

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期刊名称 Environmental Health and Toxicology
作者
Hyonok Yoon; Do-Sung Kim; Geum-Hwa Lee; Kee-Won Kim; Hyung-Ryong Kim; Han-Jung Chae;
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作者单位

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年(卷),期 2011(26),-1
年度 2011
页码 e2011017
总页数 7
原文格式 PDF
正文语种
中图分类公共卫生工程;
关键词
Apoptosis Endoplasmic reticulum stress Manganese chloride (MnCl2) Mitochondria dysfunction;

机译：凋亡;内质网应激;氯化锰（MnCl2）;线粒体功能障碍;

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专利

1. Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction [J] . Hyonok Yoon, Do-Sung Kim, Geum-Hwa Lee, Environmental Health and Toxicology . 2011,第1期

机译：锰在神经元SK-N-MC细胞系上诱导的细胞凋亡：内质网（ER）应激和线粒体功能障碍
2. Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress [J] . Hiroyuki Nakamura, Huanan Liao, Kahori Minami, Herpesviridae . 2013,第1期

机译：人类巨细胞病毒通过产生线粒体功能障碍和内质网应激来诱导诱导多能干细胞衍生的神经干/祖细胞凋亡
3. Human cytomegalovirus induces apoptosis in neural stem/progenitor cells derived from induced pluripotent stem cells by generating mitochondrial dysfunction and endoplasmic reticulum stress [J] . Hiroyuki Nakamura, Huanan Liao, Kahori Minami, Herpesviridae . 2013,第2期

机译：人类巨细胞病毒通过产生线粒体功能障碍和内质网应激来诱导源自诱导多能干细胞的神经干/祖细胞凋亡
4. Endoplasmic Reticulum Stress Signaling Pathways Is Involved in Trichosanthin-Induced Apoptosis in Human Cervical Cancer Cell Line Hela [C] . Huang Yiling, Huang Liming, You Chengcheng, 2010 4th International Conference on Bioinformatics and Biomedical Engineering . 2010

机译：内质网应激信号通路涉及天花粉蛋白诱导的人宫颈癌细胞株Hela的凋亡。
5. Mechanism of 3,3'-diindolylmethane-induced cell death in human C33A cervical cancer cells: Induction of endoplasmic reticulum stress, apoptosis and the role of growth-arrest and DNA-damage genes [D] . Han, Jing Y. 2009

机译：3,3'-二吲哚基甲烷诱导的人C33A宫颈癌细胞死亡的机制：内质网应激，细胞凋亡以及生长停滞和DNA损伤基因的作用
6. Calcium-independent Phospholipase A2 (iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis [O] . Xiaoyong Lei, Sheng Zhang, Alan Bohrer, 2008

机译：钙非依赖性磷脂酶A2 （iPLA2β）介导的神经酰胺的产生在内质网（ER）与线粒体之间的串扰应激诱导的胰岛素分泌细胞细胞凋亡
7. Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction [O] . Yoon, Hyonok, Kim, Do-Sung, Lee, Geum-Hwa, 2011

机译：锰在神经元SK-N-MC细胞系上引起的细胞凋亡：内质网（ER）应激和线粒体功能障碍

Apoptosis Induced by Manganese on Neuronal SK-N-MC Cell Line: Endoplasmic Reticulum (ER) Stress and Mitochondria Dysfunction

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