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Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study

机译：一项多基因检测的鉴定和临床验证，该检测可询问癌症干细胞的生物学特性并预测乳腺癌的转移：一项回顾性连续研究

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摘要

BackgroundBreast cancers show variations in the number and biological aggressiveness of cancer stem cells that correlate with their clinico-prognostic and molecular heterogeneity. Thus, prognostic stratification of breast cancers based on cancer stem cells might help guide patient management.

机译：背景乳腺癌显示出癌症干细胞的数量和生物学侵袭性与其临床预后和分子异质性相关。因此，基于癌干细胞的乳腺癌预后分层可能有助于指导患者管理。

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期刊名称 EBioMedicine
作者
Salvatore Pece; Davide Disalvatore; Daniela Tosoni; Manuela Vecchi; Stefano Confalonieri; Giovanni Bertalot; Giuseppe Viale; Marco Colleoni; Paolo Veronesi; Viviana Galimberti; Pier Paolo Di Fiore;
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年(卷),期 2015(42),
年度 2015
页码 352–362
总页数 11
原文格式 PDF
正文语种
中图分类
关键词
Breast cancer, Cancer stem cells, Prognostic signatures, Biomarkers, Metastasis;

机译：乳腺癌;癌症干细胞;预后标志;生物标志物;转移;

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2. Ki-67指数、孕激素受体表达、组织学分级和肿瘤大小预测乳腺癌复发风险的价值:一项连续的队列研究 [J] . 张燕娜, 周易冬, 茅枫, 癌症（英文版） . 2021,第006期
3. Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study [J] . Salvatore Pece, Davide Disalvatore, Daniela Tosoni, EBioMedicine . 2019,第4期

机译：询问癌症干细胞生物学并预测乳腺癌转移的多基因检测方法的鉴定和临床验证：一项回顾性连续研究
4. Predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort: a retrospective-prospective blinded study [J] . Buhl Anna Sofie Kappel, Christensen Troels Dreier, Christensen Ib Jarle, Breast cancer research and treatment. . 2018,第2期

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5. Cell Line Derived Multi-Gene Predictor of Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer: A Validation Study on US Oncology 02-103 Clinical Trial [J] . Kui Shen, Yuan Qi, Nan Song, BMC Medical Genomics . 2012,第1期

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6. Predicting Breast Cancer Metastasis by Integrating Both Clinical and Genetic Markers [C] . Yijun Sun, Steve Goodison International Conference on Bioinformatics and Computational Biology . 2007

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7. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

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8. Predicting efficacy of epirubicin by a multigene assay in advanced breast cancer within a Danish Breast Cancer Cooperative Group (DBCG) cohort: a retrospective-prospective blinded study [O] . Anna Sofie Kappel Buhl, Troels Dreier Christensen, Ib Jarle Christensen, -1

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Identification and clinical validation of a multigene assay that interrogates the biology of cancer stem cells and predicts metastasis in breast cancer: A retrospective consecutive study

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