Preparation and in vivo evaluation of a topical hydrogel system incorporating highly skin-permeable growth factors quercetin and oxygen carriers for enhanced diabetic wound-healing therapy

摘要

PurposeWe created and evaluated an enhanced topical delivery system featuring a combination of highly skin-permeable growth factors (GFs), quercetin (QCN), and oxygen; these synergistically accelerated re-epithelialization and granulation tissue formation of/in diabetic wounds by increasing the levels of GFs and antioxidants, and the oxygen partial pressure, at the wound site.