Nano-scaled MTCA-KKV: for targeting thrombus releasing pharmacophores inhibiting thrombosis and dissolving blood clots in vivo

机译：纳米级MTCA-KKV：在体内靶向血栓释放药效团抑制血栓形成和溶解血块

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摘要

BackgroundIn vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine.

机译：背景体外（1R，3S）-1-甲基-1,2,3,4-四氢-β-咔啉-3-羧基-Lys（Pro-Ala-Lys）-Arg-Gly-Asp-Val（MTCA-KKV ）粘附活化的血小板，靶向P-选择素和GPIIb / IIIa。这导致了MTCA-KKV作为靶向纳米药物的血栓的发展。

著录项

期刊名称 International Journal of Nanomedicine
作者
Shurui Zhao; Ze Li; Fei Huang; Jianhui Wu; Lin Gui; Xiaoyi Zhang; Yaonan Wang; Xiaozhen Wang; Shiqi Peng; Ming Zhao;
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作者单位

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年(卷),期 2019(14),-1
年度 2019
页码 4817–4831
总页数 15
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
nano-particles anti-thrombotic thrombolytic targeting release;

机译：纳米颗粒;抗血栓形成;溶栓;靶向;释放;

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专利

1. Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo [J] . Shurui Zhao, Ze Li, Fei Huang, International Journal of Nanomedicine . 2019,第1期

机译：纳米级MTCA-KKV：在体内靶向血栓，释放药效团，抑制血栓形成和溶解血块
2. Time-dependent hardening of blood clots quantitatively measured in vivo with shear-wave ultrasound imaging in a rabbit model of venous thrombosis [J] . MfoumouE., TripetteJ., BlosteinM., Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2014,第2期

机译：在兔静脉血栓形成模型中使用剪切波超声成像定量测量的体内血凝块的时间依赖性硬化
3. Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study [J] . Ashley F. Stein-Merlob, Chase W. Kessinger, S. Sibel Erdem, Theranostics . 2015,第12期

机译：静脉血栓形成中血液对血纤蛋白的可及性取决于血栓形成年龄并预测血纤蛋白溶解功效：体内血纤蛋白分子影像学研究
4. POLY (L-GLUTAMIC ACID) SEMI- INTERPENETRATING POLYMER NETWORK HYDROGEL AS A CONTOLLED RELEASE CARRIER FOR CLOT-DISSOLVING TISSUE-TYPE PLASMINOGEN ACTIVATOR [C] . Yoon-Jeong Park, Junfeng Liang, Jin Chang, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：聚（L-谷氨酸）半互穿聚合物网络水凝胶，作为可溶组织组织型纤溶酶原激活剂的受控释放载体
5. Development of controlled release microspheres for targeted drug delivery system using camptothecin as a model drug: An in vitro-in vivo correlation. [D] . Sonavaria, Vandana Jeewandas. 1994

机译：使用喜树碱作为模型药物开发靶向药物释放系统的控释微球：体内外相关性。
6. Reprogrammed streptokinases develop fibrin-targeting and dissolve blood clots with more potency than tissue plasminogen activator [O] . I. Y. SAZONOVA, R. A. MCNAMEE, A. K. HOUNG, -1

机译：重编程的链激酶在组织纤溶酶原激活物中发育纤维蛋白靶向并溶解血液凝集血栓
7. >Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo [O] . Shurui Zhao, Ze Li, Fei Huang, 2019

机译：>纳米缩放的MTCA-KKV：用于靶向血栓，释放药物，抑制体内血栓形成和溶解血栓

Nano-scaled MTCA-KKV: for targeting thrombus releasing pharmacophores inhibiting thrombosis and dissolving blood clots in vivo

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