EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles a new diagnostic tool and drug carrier for atherosclerosis

机译：EGFP-EGF1偶联的聚乳酸-乙醇酸纳米颗粒一种新的诊断工具和动脉粥样硬化的药物载体

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摘要

BackgroundEGFP-EGF1-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticle (ENP) has a specific affinity to tissue factor (TF). The aim of this study was to investigate the target delivery of ENP to plaques and its uptake in a mouse model of atherosclerosis in vivo and in vitro.

机译：背景EGFP-EGF1缀合的聚乳酸-乙醇酸共聚物（PLGA）纳米颗粒（ENP）对组织因子（TF）具有特定的亲和力。这项研究的目的是研究在体内和体外动脉粥样硬化小鼠模型中ENP向斑块的靶向递送及其摄取。

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期刊名称 International Journal of Nanomedicine
作者
Zhilin Wu; Chen Chen; Bo Zhang; Liang Tang; Wei Shi; Danying Liao; Gaohong Di; Jacques RJ Davis; Hui Wang;
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作者单位

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年(卷),期 2019(14),-1
年度 2019
页码 2609–2618
总页数 10
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
tissue factor atherosclerosis nanoparticle target delivery EGFP-EGF1;

机译：组织因子;动脉粥样硬化;纳米颗粒;靶标传递;EGFP-EGF1;

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专利

1. EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles, a new diagnostic tool and drug carrier for atherosclerosis [J] . Zhilin Wu, Chen Chen, Bo Zhang, International Journal of Nanomedicine . 2019,第2期

机译：EGFP-EGF1共轭的聚乳酸-乙醇酸纳米颗粒，一种新的诊断工具和动脉粥样硬化的药物载体
2. Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(beta-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma [J] . Zhang Cong, An Tong, Wang Dan, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2016,第Null期

机译：逐步pH响应纳米颗粒，包含基于电荷可逆的支链淀粉基壳和聚（β-氨基酯）/聚（乳酸-共-乙醇酸）核作为抗癌药物载体，用于肝细胞癌的联合治疗
3. A method for the prediction of drug content of poly(lactic-co-glycolic)acid drug carrier nanoparticles obtained by nanoprecipitation [J] . Tünde Tóth, éva Kiss Journal of drug delivery science and technology . 2019,第期

机译：一种预测纳米尺寸获得的聚（乳酸共甘油）酸药物载体纳米颗粒的药物含量的方法
4. Characterization of a Dynamic Poly(lactic-co-glycolic acid) Core + Poly (N-isopropylacrylamide) Shell Nanoparticle System for Targeted Drug Delivery Applications [C] . Aaron M. Kosinski, Jamie L. Brugnano, Brandon L. Seal, Society for Biomaterials fall symposium 2012.;vol. 34. . 2012

机译：动态聚（乳酸-乙醇酸）核心+聚（N-异丙基丙烯酰胺）壳纳米粒子系统的靶向药物传递应用的表征。
5. Synthesis and Characterization of Silicate Ester Prodrugs and Poly(ethylene glycol)-b-poly(lactic-co-glycolic acid) Block Copolymers for Formulation into Prodrug-Loaded Nanoparticles. [D] . Wohl, Adam Richard. 2012

机译：硅酸酯酯前药和聚（乙二醇）-b-聚（乳酸-共-乙醇酸）嵌段共聚物的合成和表征，用于配制成载有前药的纳米颗粒。
6. Dual tumor-targeted poly(lactic-co-glycolic acid)–polyethylene glycol–folic acid nanoparticles: a novel biodegradable nanocarrier for secure and efficient antitumor drug delivery [O] . Jia Chen, Qi Wu, Li Luo, 2017

机译：双重靶向肿瘤的聚乳酸-乙醇酸-聚乙二醇-叶酸纳米颗粒：一种新型可生物降解的纳米载体可安全有效地递送抗肿瘤药物
7. >EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles, a new diagnostic tool and drug carrier for atherosclerosis [O] . Zhilin Wu, Chen Chen, Bo Zhang, 2019

机译：> EGFP-EGF1 - 缀合的聚（乳酸二乙醇酸）纳米颗粒，用于动脉粥样硬化的新诊断工具和药物载体

EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles a new diagnostic tool and drug carrier for atherosclerosis

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