Controlled release of paclitaxel from a self-assembling peptide hydrogel formed in situ and antitumor study in vitro

摘要

BackgroundA nanoscale injectable in situ-forming hydrogel drug delivery system was developed in this study. The system was based on a self-assembling peptide RADA16 solution, which can spontaneously form a hydrogel rapidly under physiological conditions. We used the RADA16 hydrogel for the controlled release of paclitaxel (PTX), a hydrophobic antitumor drug.