Thymoquinone-loaded nanostructured lipid carriers: preparation gastroprotection in vitro toxicity and pharmacokinetic properties after extravascular administration

摘要

BackgroundNanostructured lipid carriers (NLCs), composed of solid and liquid lipids, and surfactants are potentially good colloidal drug carriers. Thymoquinone is the main bioactive compound of Nigella sativa. In this study, the preparation, gastroprotective effects, and pharmacokinetic (PK) properties of thymoquinone (TQ)-loaded NLCs (TQNLCs) were evaluated.