Nanoemulsion loaded with lycobetaine–oleic acid ionic complex: physicochemical characteristics in vitro in vivo evaluation and antitumor activity

摘要

BackgroundIntravenous injection of lycobetaine was found to show significant cytotoxic activity against (inter alia) Lewis lung carcinoma, but its therapeutic use is largely limited due to an extremely short half-life in blood. This study aimed at developing a novel lipid nanocarrier-based formulation for lycobetaine delivery. The formulation is feasible for scale-up production, exhibiting good parenteral acceptability and improved circulation characteristics.