Improved In Vitro and In Vivo Antitumor Activity of 5-fluorouracil-loaded PEGylated BolasurfactantNiosomes

摘要

Innovative niosomes made up of ,-hexadecyl-bis-(1-aza-18-crown-6) (bola), Span 80(R), cholesterol and N-(carbonyl-methoxypolyethylene glycol-2000)-1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPEMPEG2000) (2:5:2:0.1 molar ratio) are proposed assuitable delivery systems for the administration of 5-fluorouracil (5-FU), an antitumoral compound largelyused in the treatment of breast cancer. In vitro cytotoxictests on MCF-7 and T47D cells and in vivo experimentson MCF-7 xenograft tumor SCID mice models showed amore effective antitumoral activity of the 5-FU-loadedPEGylated niosomal with respect to the free drug.