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Asperversins A and B Two Novel Meroterpenoids with an Unusual 5/6/6/6 Ring from the Marine-Derived Fungus Aspergillus versicolor

机译:Asperversins A和B两个新颖的类萜类化合物它们来自海洋衍生真菌杂色曲霉具有异常的5/6/6/6环

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摘要

Asperversins A (>1) and B (>2), two novel meroterpenoids featuring an uncommon 5/6/6/6 ring system, along with five new analogues (>3–>7) and a known compound asperdemin (>8), were obtained from the marine-derived fungus Aspergillus versicolor. Their structures and absolute configurations were confirmed by extensive spectroscopic analyses, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculation. All new compounds were tested for their acetylcholinesterase enzyme (AChE) inhibitory activities and cytotoxic activities, of which compound >7 displayed moderate inhibitory activity against the AChE with an IC50 value of 13.6 μM.
机译:曲霉菌素A(> 1 )和B(> 2 ),是两个具有罕见5/6/6/6环系统的新型金属萜类化合物,以及五个新的类似物(> 3 – > 7 )和一种已知的化合物曲霉菌素(> 8 )是从海洋真菌杂色曲霉中获得的。它们的结构和绝对构型已通过广泛的光谱分析,单晶X射线衍射研究和电子圆二色性(ECD)计算得到了证实。测试所有新化合物的乙酰胆碱酯酶(AChE)抑制活性和细胞毒性活性,其中化合物> 7 对AChE表现出中等抑制活性,IC50值为13.6μM。

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