New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151

摘要

Six new diketopiperazines, (±)-7,8-epoxy-brevianamide Q ((±)->1), (±)-8-hydroxy-brevianamide R ((±)->2), and (±)-8-epihydroxy-brevianamide R ((±)->3), together with four known compounds, (±)-brevianamide R ((±)->4), versicolorin B (>5) and averufin (>6), were isolated from a marine-derived fungus strain Aspergillus versicolor , which was recovered from a sediment sample collected from the Bohai Sea, China. The chemical structures were established by 1D- and 2D-NMR spectra and HR-ESI-MS. >1 is the first sample of brevianamides with an epoxy moiety. Their bioactivities were evaluated against Candida albicans, Bacillus subtilis, Staphylococcus aureus, methicillin-resistant S. aureus, Pseudomonas aeruginosa, and Bacillus Calmette-Guérin. Compounds >1–>4 showed no activities against the pathogens, and compounds >5 and >6 showed moderate activities against S. aureus and methicillin-resistant S. aureus.