With advances in diagnostic techniques and treatment modalities, the number of patients identified with colorectal carcinoma who develop multiple primary malignancies during long-term followup has been increasing. We report a patient who developed three histologically distinct malignancies. Primary colon carcinoma treated radically followed by an 8-year disease-free period. The patient then presented with progressive dysphagia and was investigated and diagnosed to have a synchronous multicentric squamous cell carcinoma of the oesophagus and basal cell carcinoma of the skin. There was a simultaneous multicentric recurrence in the colon. This case is worth mentioning because the clustering of three primary malignancies (synchronous and metachronous) is of rareoccurrence in a single patient, and, to ourknowledge, this is the first report of thiscombination occurring in the sameindividual. In addition, the report emphasizesthe importance of evaluating patients with knowncolonic primary neoplasms for synchronouscolonic and extracolonic tumors.
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