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High frequency of mutations in gyrA gene associated with quinolones resistance in uropathogenic Escherichiacoli isolates from the north of Iran

机译：尿毒症大肠埃希菌中与喹诺酮类耐药有关的gyrA基因突变频率很高来自伊朗北部的大肠杆菌分离株

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Objective(s):Regarding the global burden of uropathogenic Escherichia coli (UPEC) infections, prevention and treatment of such infections play a significant role in healthcare management. The inordinate use of fluoroquinolones led to a worldwide spread of quinolone-resistant strains. Therefore, this study aimed to investigate mutations in codons 83 and 106 of gyrA gene in UPEC isolates in the north of Iran.

机译：目标：关于泌尿道致病性大肠埃希菌（UPEC）感染的全球负担，预防和治疗此类感染在医疗保健管理中起着重要作用。氟喹诺酮类药物的过度使用导致喹诺酮抗性菌株在全球范围内传播。因此，本研究旨在调查伊朗北部UPEC分离株中gyrA基因密码子83和106的突变。

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期刊名称 Iranian Journal of Basic Medical Sciences
作者
Mohammad Shenagari; Masoud Bakhtiari; Ali Mojtahedi; Zahra Atrkar Roushan;
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年(卷),期 2018(21),12
年度 2018
页码 1226–1231
总页数 6
原文格式 PDF
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专利

1. Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates. [J] . Ruiz J, Goni P, Marco F, Microbiology and Immunology . 1998,第3期

机译：空肠弯曲杆菌对喹诺酮类药物的耐药性增加：对喹诺酮类耐药的临床分离株中gyrA基因突变的遗传分析。
2. Detection of Quinolone Resistance in Salmonella typhimurium Pig Isolates Determined by gyrA Gene Mutation Using PCR- and Sequence-Based Techniques within the gyrA Gene [J] . Macias Farrera Guadalupe Patricia, Tenorio Borroto Esvieta, Rivera Ramirez Fabiola, Current pharmaceutical design . 2016,第33期

机译：使用gyrA基因内基于PCR和基于序列的技术检测由gyrA基因突变确定的鼠伤寒沙门氏菌猪分离株的喹诺酮耐药性
3. The Frequency of Mutations in Quinolone Resistance-Determining Regions and Plasmid-Mediated Quinolone Resistance in Shigella Isolates Recovered from Pediatric Patients in Tehran, Iran: An Overlooked Problem [J] . Yaghoubi Sajad, Ranjbar Reza, Dallal Mohammad Mehdi Soltan, Microbial drug resistance: MDR : Mechanisms, epidemiology, and disease . 2018,第6期

机译：在德黑兰小儿患者中回收的喹啉抗性测定区突变突变频率和质粒介导的血红素介导的喹啉抗性，伊朗（伊朗）
4. Genetic analysis of the 15kD nucleocapsed protein coding gene (ORF 7) of North American PRRS virus isolates [C] . L. Yang, K.-J. Yoon, J.-H. Lee, Congress of the International Pig Veterinary Society . 1999

机译：北美PRRS病毒分离株15KD核衣壳蛋白编码基因（ORF 7）的遗传分析
5. Data mining tool for correlating drug resistance with genomic mutations in Mycobacterium tuberculosis isolates [D] . Didulo, Dennis 2015

机译：关联结核分枝杆菌菌株耐药性与基因组突变的数据挖掘工具
6. Detection of gyrA and gyrB mutations in quinolone-resistant clinical isolates of Escherichia coli by single-strand conformational polymorphism analysis and determination of levels of resistance conferred by two different single gyrA mutations. [O] . S Ouabdesselam, D C Hooper, J Tankovic, 1995

机译：通过单链构象多态性分析检测喹诺酮耐药性大肠杆菌临床分离株中的gyrA和gyrB突变并确定两个不同的单个gyrA突变赋予的耐药水平。
7. Detection of gyrA and gyrB mutations in quinolone-resistant clinical isolates of Escherichia coli by single-strand conformational polymorphism analysis and determination of levels of resistance conferred by two different single gyrA mutations. [O] . Ouabdesselam, S, Hooper, D C, Tankovic, J, 1995

机译：通过单链构象多态性分析检测喹诺酮耐药的临床大肠杆菌中的gyrA和gyrB突变，并确定两个不同的单个gyrA突变赋予的耐药水平。

High frequency of mutations in gyrA gene associated with quinolones resistance in uropathogenic Escherichiacoli isolates from the north of Iran

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