Alterations in adult hippocampal neurogenesis aberrant protein s-nitrosylation and associated spatial memory loss in streptozotocin-induced diabetes mellitus type 2 mice

摘要

Objective(s):Epidemiological and biochemical studies conducted over the past two decades have established a strong link between type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). However, the exact mechanisms through which aberrations in insulin signaling associated with T2DM contribute to cognitive decline are not yet known.